An aminoglycoside with an outstanding feature of being little or not affected by majority of inacti vating enzymes is-
**Core Concept**
Aminoglycoside antibiotics are a class of drugs that inhibit protein synthesis by binding to the 30S subunit of the bacterial ribosome. One of the key features of aminoglycosides is their susceptibility to inactivation by various enzymes produced by bacteria, which can significantly reduce their effectiveness.
**Why the Correct Answer is Right**
The aminoglycoside antibiotic Tobramycin is an exception to this rule, as it is relatively resistant to inactivation by the majority of aminoglycoside-modifying enzymes (AMEs). This is due to its unique chemical structure, which makes it less accessible to the enzymes that typically inactivate aminoglycosides. Tobramycin's resistance to inactivation allows it to retain its antibacterial activity in the presence of these enzymes, making it a valuable option for treating infections caused by resistant bacteria.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as it does not specify an aminoglycoside antibiotic that is resistant to inactivation by AMEs.
**Option B:** This option is incorrect as it does not accurately describe the unique feature of Tobramycin.
**Option C:** This option is incorrect as it does not mention the specific aminoglycoside antibiotic that is resistant to inactivation by AMEs.
**Clinical Pearl / High-Yield Fact**
Tobramycin's resistance to inactivation by AMEs makes it a valuable option for treating infections caused by bacteria that produce these enzymes, such as certain strains of Pseudomonas aeruginosa.
**Correct Answer:** C. Tobramycin