**Core Concept**
The question is testing the student's knowledge of amino acid metabolism, specifically the transamination reaction that leads to the production of oxaloacetate. Oxaloacetate is a key intermediate in the citric acid cycle, and its production is critical for energy metabolism in the cell.
**Why the Correct Answer is Right**
Aspartate is directly converted to oxaloacetate through a transamination reaction, which is catalyzed by the enzyme aspartate aminotransferase (also known as glutamate-oxaloacetate transaminase). This reaction involves the transfer of an amino group from aspartate to alpha-ketoglutarate, resulting in the formation of glutamate and oxaloacetate. This is a critical step in the metabolism of aspartate, as it allows for the production of oxaloacetate, which can then enter the citric acid cycle.
**Why Each Wrong Option is Incorrect**
**Option A:** Alanine is converted to pyruvate through a transamination reaction, but it does not produce oxaloacetate directly.
**Option B:** Cysteine is not directly involved in the production of oxaloacetate through a transamination reaction.
**Option C:** Threonine is also not directly involved in the production of oxaloacetate through a transamination reaction.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that the transamination reaction is a critical step in the metabolism of amino acids, and it allows for the production of key intermediates such as oxaloacetate, which can then enter the citric acid cycle.
**Correct Answer:**
β Correct Answer: D. Aspartate
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
Access thousands of free MCQs, ebooks and daily exams.
By signing in you agree to our Privacy Policy.