Amiloride can cause hyperkalemia due to its action on :
Correct Answer: Electrogenic Na+ channels
Description: Amiloride and triamterene are K+ sparing diuretics that act by inhibiting epithelial Na+ channels.
In the distal tubules and collecting ducts, three separate channels are present (one for Na+, K+ and H+ each). Aldosterone acts on DCT and CD to cause reabsorption of Na+. This generates a lumen negative potential difference across the membrane of this part of the nephron. To maintain the electric neutrality, K+ and H+ are secreted in the lumen.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now