## **Core Concept**
The amyloid precursor protein (APP) plays a critical role in the pathogenesis of Alzheimer's disease. APP is a transmembrane protein that, when cleaved by specific enzymes, can lead to the production of amyloid-beta peptides, which are major components of amyloid plaques found in the brains of Alzheimer's patients.

## **Why the Correct Answer is Right**
The correct enzymes responsible for cleaving the amyloid precursor protein (APP) in Alzheimer's disease are **beta-secretase** (also known as BACE1) and **gamma-secretase**.
- **Beta-secretase** initiates the cleavage of APP by cutting it at the N-terminus of the amyloid-beta peptide, producing a soluble fragment and a membrane-bound C-terminal fragment.
- **Gamma-secretase** then cleaves the C-terminal fragment within the membrane, releasing the amyloid-beta peptide into the extracellular space.
These amyloid-beta peptides can aggregate to form insoluble fibrils that deposit as amyloid plaques, a hallmark of Alzheimer's disease.

## **Why Each Wrong Option is Incorrect**
- **Option A:** This option is incorrect because it does not specify the correct enzymes involved in APP cleavage.
- **Option B:** This option might mention one correct enzyme but lacks the second correct enzyme, **gamma-secretase**, or mentions incorrect ones.
- **Option D:** Similarly, this option does not accurately represent the enzymes **beta-secretase** and **gamma-secretase**.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that the inhibition of **beta-secretase** (BACE1) and **gamma-secretase** are potential therapeutic strategies for Alzheimer's disease, aimed at reducing amyloid-beta production.

## **Correct Answer:** C.