**Core Concept**
Alzheimer's disease is a neurodegenerative disorder characterized by progressive cognitive decline and memory loss. It is primarily associated with the degeneration of neurons in specific regions of the brain.

**Why the Correct Answer is Right**
The correct answer involves the temporoparietal cortex, which is responsible for processing and integrating sensory information, including visual and auditory inputs. The temporoparietal cortex is also crucial for memory formation and retrieval. In Alzheimer's disease, atrophy of this region leads to impaired memory and cognitive function. This is due to the accumulation of amyloid beta plaques and tau protein tangles, which disrupt neuronal communication and lead to neuronal death.

**Why Each Wrong Option is Incorrect**
**Option A:** The frontal cortex is involved in executive functions, such as decision-making, planning, and motor control. While Alzheimer's disease can affect the frontal cortex, it is not the primary region involved.

**Option C:** The frontal and parietal cortices are indeed affected in Alzheimer's disease, but the primary region involved is the temporoparietal cortex.

**Option D:** The occipital cortex is primarily responsible for processing visual information and is not directly involved in the pathophysiology of Alzheimer's disease.

**Clinical Pearl / High-Yield Fact**
It is essential to note that Alzheimer's disease is a heterogeneous disorder, and various regions of the brain, including the hippocampus and the basal forebrain, are also affected. However, the temporoparietal cortex is a hallmark of the disease, and atrophy in this region is a key diagnostic feature.

**✓ Correct Answer: B. Coical atrophy of temporoparietal coex**