Alpha,anti trypsin deficiency causes
Correct Answer: panacinar emphysema
Description: Ans b (panacinar -emphysema) Ref Harrison 17th pg 1638Emphysema is classified into distinct pathologic types, the most important being centriacinar and panacinar.Centriacinar emphysema -cigarette smoking- enlarged airspaces in association with respiratory bronchioles- upper lobes and superior segments of lower lobes and is often quite focal.Panacinar emphysema - large airspaces evenly distributed within and across acinar units-Alpha! AT deficiency- lower lobes.Risk factors for the development of COPDTobacco smokeBiomass solid fuel firesOccupational -Coal miners & cadmiumAir pollutionLow birth weightChildhood infections & maternal smoking
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