Alpha-fetoprotein in maternal serum and/or amniotic fluid is increased in all except
Correct Answer: Down's syndrome
Description: In Down syndrome, the AFP is decreased in the mother's blood, presumably because the yolk sac and fetus are smaller than usual. Estriol is a hormone produced by the placenta, using ingredients made by the fetal liver and adrenal gland. Estriol is decreased in the Down syndrome pregnancy Ref Robbins 9/e pg 170
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