All true about effect of propofol on Respiratory system except-
**Core Concept**
Propofol is a commonly used intravenous anesthetic agent that affects the respiratory system by modulating neurotransmitter release, depressing the activity of the respiratory centers in the brainstem, and reducing the sensitivity of respiratory muscles to neural stimulation.
**Why the Correct Answer is Right**
Propofol causes a dose-dependent decrease in the activity of the medulla oblongata, leading to a decrease in the respiratory rate and depth. This is mediated through the inhibition of GABA receptors in the brainstem, which results in a decrease in the excitability of the respiratory centers. Additionally, propofol reduces the sensitivity of the diaphragm and other respiratory muscles to neural stimulation, further contributing to respiratory depression.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect as propofol does indeed cause respiratory depression, but the statement is incomplete and does not address the effect of propofol on the respiratory system.
**Option B:** This option is incorrect as propofol does cause a decrease in respiratory rate and depth, but does not directly stimulate the respiratory system.
**Option C:** This option is incorrect as propofol does not cause an increase in respiratory rate and depth. In fact, it causes a significant decrease in respiratory drive.
**Option D:** This option is incorrect as propofol does not cause a significant increase in the sensitivity of respiratory muscles to neural stimulation. Instead, it reduces the sensitivity of these muscles.
**Clinical Pearl / High-Yield Fact**
One important clinical consideration when using propofol is to monitor the patient's respiratory status closely, especially in patients with pre-existing respiratory disease or those who are at risk for respiratory depression.
**Correct Answer: A.**