All statements are true for osteomalacia except: March 2012
**Core Concept**
Osteomalacia is a condition characterized by the softening of bones due to impaired bone mineralization. It is often caused by a deficiency of vitamin D, which plays a crucial role in calcium absorption and bone health. Vitamin D deficiency can lead to an imbalance in calcium and phosphate levels, causing the bones to become soft and pliable.
**Why the Correct Answer is Right**
The correct answer is related to the underlying pathophysiology of osteomalacia. Osteomalacia is indeed caused by a deficiency of vitamin D, which affects the absorption of calcium and phosphate from the gut. This leads to a decrease in the levels of calcium and phosphate in the blood, causing the bones to become soft and prone to fractures. The bones in osteomalacia are also characterized by an increase in osteoid tissue, which is unmineralized bone matrix.
**Why Each Wrong Option is Incorrect**
**Option A:** Osteomalacia is not caused by an excess of vitamin D. In fact, vitamin D toxicity can cause hypercalcemia, which is a condition characterized by elevated levels of calcium in the blood.
**Option B:** Osteomalacia is indeed associated with a deficiency of vitamin D, which affects the absorption of calcium and phosphate from the gut. This statement is true.
**Option C:** Osteomalacia is indeed a condition characterized by the softening of bones due to impaired bone mineralization. This statement is true.
**Option D:** Osteomalacia is not caused by an excess of phosphate. In fact, a deficiency of phosphate can also contribute to the development of osteomalacia.
**Clinical Pearl / High-Yield Fact**
One important clinical pearl to remember is that osteomalacia can be distinguished from rickets, which is a similar condition affecting children, by the presence of bone pain and muscle weakness in adults with osteomalacia.
**Correct Answer: C. Osteomalacia is a condition characterized by the softening of bones due to impaired bone mineralization.**