All seen in multiple myeloma, Except –
**Core Concept**
Multiple myeloma is a plasma cell malignancy characterized by the proliferation of clonal plasma cells in the bone marrow, leading to bone destruction, anemia, and immunodeficiency. The disease is associated with hypercalcemia, renal failure, and anemia due to the production of abnormal proteins by the malignant plasma cells.
**Why the Correct Answer is Right**
The correct answer is related to the pathophysiology of multiple myeloma. The disease is characterized by the production of abnormal proteins, including monoclonal immunoglobulins (M-proteins), which can cause hypercalcemia, renal failure, and anemia. The M-proteins can also lead to the formation of amyloid deposits in various tissues. Additionally, multiple myeloma is associated with bone destruction, which can result in osteolytic lesions and hypercalcemia.
**Why Each Wrong Option is Incorrect**
**Option A:** Hyperglycemia is not typically seen in multiple myeloma. While patients with multiple myeloma may have diabetes mellitus, the disease itself is not associated with hyperglycemia.
**Option B:** Amyloidosis is a known complication of multiple myeloma, characterized by the deposition of amyloid fibrils in various tissues.
**Option C:** Bone pain is a common symptom of multiple myeloma, resulting from bone destruction and osteolytic lesions.
**Option D:** Anemia is a hallmark of multiple myeloma, resulting from the proliferation of malignant plasma cells in the bone marrow and the production of abnormal proteins.
**Clinical Pearl / High-Yield Fact**
Multiple myeloma is often diagnosed incidentally during laboratory tests for unrelated conditions, highlighting the importance of monitoring for abnormal protein production and bone destruction in patients with a history of malignancy.
**Correct Answer:** A. Hyperglycemia