All of the statements are true about Brugada syndrome, EXCEPT:
**Brugada Syndrome**
**Core Concept**
Brugada syndrome is a genetic disorder characterized by abnormal electrocardiographic (ECG) findings and an increased risk of sudden cardiac death due to ventricular fibrillation. It is caused by mutations in genes encoding cardiac sodium channels.
**Why the Correct Answer is Right**
Brugada syndrome is associated with a coved-type ST-segment elevation in the right precordial leads (V1-V2) on an ECG, which is a hallmark diagnostic feature. The syndrome is often linked to mutations in the SCN5A gene, which encodes the alpha-subunit of the cardiac sodium channel. These mutations disrupt normal sodium channel function, leading to abnormal electrical activity in the heart.
**Why Each Wrong Option is Incorrect**
**Option A:** Brugada syndrome is indeed a genetic disorder, often inherited in an autosomal dominant pattern. This statement is true.
**Option B:** The characteristic ECG findings of Brugada syndrome include a coved-type ST-segment elevation in the right precordial leads (V1-V2), which is a hallmark diagnostic feature. This statement is true.
**Option C:** Brugada syndrome is associated with an increased risk of sudden cardiac death due to ventricular fibrillation. This statement is true.
**Option D:** Brugada syndrome is not typically associated with a prolonged QT interval on an ECG. Instead, it is characterized by a coved-type ST-segment elevation in the right precordial leads. This statement is false, making it the correct answer.
**Clinical Pearl / High-Yield Fact**
A classic ECG finding in Brugada syndrome is a coved-type ST-segment elevation in the right precordial leads (V1-V2), often accompanied by a saddleback or "coved" appearance. This distinctive ECG pattern is a key diagnostic clue for the syndrome.
**Correct Answer: D. Brugada syndrome is not typically associated with a prolonged QT interval on an ECG.**