## Core Concept
Linezolid is an oxazolidinone antibiotic used to treat infections caused by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). It works by inhibiting bacterial protein synthesis. However, like all medications, it can cause side effects and toxicities.
## Why the Correct Answer is Right
The correct answer, , is associated with linezolid's side effect profile. Linezolid is known to cause myelosuppression (Option A), neuropathy with prolonged use (Option B), and lactic acidosis (Option C). However, among the provided options, is not commonly recognized as a direct toxicity of linezolid.
## Why Each Wrong Option is Incorrect
- **Option A:** Myelosuppression is a known side effect of linezolid, which can lead to anemia, thrombocytopenia, and leukopenia.
- **Option B:** Neuropathy, particularly peripheral neuropathy, can occur with prolonged use of linezolid.
- **Option C:** Lactic acidosis is a recognized but rare side effect of linezolid.
## Clinical Pearl / High-Yield Fact
A key point to remember about linezolid is its potential for causing myelosuppression, especially with prolonged use (> 2 weeks). Monitoring of complete blood counts (CBC) is recommended for patients receiving linezolid for extended periods.
## Correct Answer: D.
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