Digoxin remains one of the most frequently prescribed drugs in the management of atrial fibrillation. The main indications for digoxin in atrial fibrillation are restoration of sinus rhythm, prevention of recurrence and slowing of the ventricular rate Other common dysrhythmias associated with digoxin toxicity include: Frequent PVCs (the most common abnormality), including ventricular bigeminy and trigeminy. Regularised AF = AF with complete hea block and a junctional or ventricular escape rhythm. Ventricular tachycardia, including polymorphic and bidirectional VT Adenosine can, at times, terminate the rhythm, but not always. Ablation of atrial tachycardia is also an option, especially when medical therapy fails. Special Situations: Atrial tachycardia with 2:1 block; when atrial tachycardia occurs with a 2:1 conduction block digoxin is best and toxicity should be considered Ref Davidson 23rd edition pg 460