All of the following statements regarding Sickle Cell Anemia is true, EXCEPT:
Correct Answer: Patients usually presents before the age of 6 months
Description: Sickle cell anemia is an autosomal recessive disorder, caused by an amino acid substitution of valine for glutamine in the sixth position on the beta-globin chain. Onset of the disease stas during the first year of life especially after 6 months of age, when hemoglobin F levels falls, as a signal is sent to switch from production of gamma globin to beta globin. Hemoglobin S is unstable and polymerizes during hypoxemia and acidosis, leading to sickling of red blood cells. Patients develops jaundice, pigmented gallstones, spleenomegaly, and poorly healing ulcers over the lower tibia. Acute painful episodes can occur due to acute vaso-occlusion by clusters of sickled red cells during infection, dehydration, or hypoxia. Common sites of acute painful episodes include the bones and the chest. Ref: Current Medical Diagnosis and Treatment 2012, Chapter 13 ; Medical Assisting: Administrative and Clinical Competencies By Lucille Keir, 6th Edition, Page 471
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now