Pharmacology All of the following statements regarding bioavailability of a drug are true, EXCEPT: A It is the fraction of unchanged drug that reaches the systemic circulation B Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous (iv) administration of the drug C Low oral bioavailability always and necessarily mean poor absorption D Bioavailability can be determined from plasma concentration or urinary excretion data. 💡 Explanation All of the following statements regarding bioavailability of a drug are true, EXCEPT: ✓ Correct Answer: C. Low oral bioavailability always and necessarily mean poor absorption