Pharmacology All of the following statements regarding bioavailability of a drug are true except: A It is a fraction of administered drug that reaches the systemic circulation in unchanged form B Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous administration C Low oral availability always and necessarily means poor absorption D Bioavailability can be determined from plasma concentration or urinary excretion data. 💡 Explanation All of the following statements regarding bioavailability of a drug are true except: ✓ Correct Answer: C. Low oral availability always and necessarily means poor absorption