All of the following statements regarding bioavailability of a drug are true except:

A. It is a fraction of administered drug that reaches the systemic circulation in unchanged form

B. Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous administration

C. Low oral availability always and necessarily means poor absorption

D. Bioavailability can be determined from plasma concentration or urinary excretion data.

Correct Answer: Low oral availability always and necessarily means poor absorption

Description: - Bioavailability is the fraction of administered drug that reaches systemic circulation in unchanged form. So it depends on Absorption and first pass metabolism. - In case of oral bioavailability, it may be low due to decreased absorption or high first pass metabolism.

Category: Pharmacology

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