Pathology All of the following statements are true related to histamine, except: A Histamine is a principal mediator of immediate transient response during acute inflammation. B It causes dilation of aerioles C It increases the permeability of venules D Histamine receptor agonists are used to treat allergies. 💡 Explanation All of the following statements are true related to histamine, except: ✓ Correct Answer: D. Histamine receptor agonists are used to treat allergies.