Medical MCQ - All of the following statements are true regarding carbimazole as compared to propylthiouracil except?

All of the following statements are true regarding carbimazole as compared to propylthiouracil except?

Carbimazole cross placenta less than propylthiouracil

Carbimazole is more potent than propylthiouracil

Carbimazole can be used as single daily dose whereas propylthiouracil needs to given thrice a day

Carbimazole does not inhibit peripheral conversion of T4 to T3

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Correct Answer:

Carbimazole cross placenta less than propylthiouracil

Description:

Propylthiouracil has less transfer across placenta, so is preferred in first trimester of pregnancy. Propey Carbimazole PTU Potency Plasma half life Frequency of dosing Plasma protein binding Transfer across placenta Peripheral conversion Hepatotoxicity High More Once a day High High No effect Absent Low Less Thrice a day Low Low Inhibits Present

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