All of the following statements about phenytoin are true except:

A. It follows Saturation kinetics

B. Anti-seizure activity closely resembles plasma concentration

C. Does not depress CNS

D. Cerebellar degeneration occurs on long-term administration

Correct Answer: Cerebellar degeneration occurs on long-term administration

Description: Phenytoin is not a CNS depressant; some sedation occurs at therapeutic doses, but this does not increase fuher with dose; rather toxic doses produce excitement and muscular rigidity. REF: ESSENTIALS OF MEDICAL PHARMACOLOGY KD TRIPATHI 8TH ED.

Category: Pharmacology

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