All of the following statements about Myasthenia Gravis are true, except:
Correct Answer: Anti-MuSK antibodies are directed against muscarinic ACh receptors
Description: Anti-MuSK antibodies are autoantibodies directed against muscle-specific tyrosine kinase (MuSK) Anti-ChR antibodies and Anti-MuSK Antibodies directed against muscle-specific tyrosine kinase (MuSK) Anti-AChR antibodies are the most common antibodies in generalized myasthenia gravis. The pathogenic antibodies aee IgG and are T cell dependent The chief target of the autoimmune attack (Anti-AChR antibodies) in most cases of myasthenia gravis is the skeletal muscle nicotinic acetylcholine receptor (nAChR) The underlying defect is a decrease in the number of available Nicotinic ACh Receptors (nAChR) on the motor end plate at the "Neuromuscular junction" due to an antibody mediated autoimmune attack. Anti-MuSK antibody occurs in about 40% of patients without AChR antibody. Muscle -specific kinase (MuSK) is a protein involved in AChR clustering at neuromuscular junctions. An immune response to muscle-specific kinase (MuSK), can also result in MG, with reduction of AChR demonstrated experimentally. Anti-MuSK antibody occurs in about 40% of patients without AChR antibody. Ref: Harrison&;s 19th edition Pgno: 2701
Category:
Physiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now