All of the following statements about antianginal action of nitrates are true except?
Correct Answer: Total coronary flow
Description: Ans. is 'c' i.e., Total coronary flow Pharmacological actions of nitrates The only major action is direct nonspecific smooth muscle relaxation. The most prominant action is exeed on vascular smooth muscles. Preload reduction - Nitrates dilate veins more than aeries decreased venous return (preload) - decreased end diastolic size and pressure - decreased O2 consumption. Afterload reduction - Nitrates also produce some aeriolar dilatation - slightly decreased total peripheral resistance (afterload). Redistribution of coronary flow. Other smooth muscles - Nitrates cause relaxation of bronchi, biliary tract, esophagus - can be used in biliary colic and esophageal spasm.
Category:
Pharmacology
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