Pathology All of the following regarding acute graft rejection are true, except: A CD8+ T-cells directly destroy the graft B It is the principal cause of early graft failure C Preformed antibodies against graft are the main causative factor D Cytokines secreted by CD4+ T-cells cause inflammation which destroys the graft 💡 Explanation All of the following regarding acute graft rejection are true, except: ✓ Correct Answer: C. Preformed antibodies against graft are the main causative factor