All of the following regarding acute graft rejection are true, except:
Correct Answer: Preformed antibodies against graft are the main causative factor
Description: Hyperacute rejection is mediated by preformed antibodies specific for antigens on graft endothelial cells. Acute graft rejection: It occurs within days or weeks after transplantation and is the principal cause of early graft failure. Divided into two types: In acute cellular rejection, CD8+ CTLs may directly destroy graft cells, or CD4+ cells secrete cytokines and induce inflammation, which damages the graft. In acute antibody-mediated (vascular, or humoral) rejection, antibodies bind to vascular endothelium and activate complement the classical pathway
Category:
Pathology
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