**Core Concept**
Hirsutism in females is a condition characterized by excessive hair growth in androgenetic areas such as the face, chest, and back. It is often caused by an excess of androgens, which can be due to various factors including polycystic ovary syndrome (PCOS), congenital adrenal hyperplasia, or an androgen-secreting tumor.

**Why the Correct Answer is Right**
Treatment for hirsutism typically involves reducing androgen levels or blocking their effects on the body. This can be achieved through medications such as spironolactone, a potassium-sparing diuretic that also acts as an anti-androgen. Another option is flutamide, a nonsteroidal anti-androgen that blocks the effects of androgens on the body. However, some medications are not suitable for treating hirsutism.

**Why Each Wrong Option is Incorrect**
**Option A:** **Spironolactone** is actually a correct option for treating hirsutism, as it blocks the effects of androgens on the body.
**Option B:** **Flutamide** is also a correct option for treating hirsutism, as it blocks the effects of androgens on the body.
**Option C:** **Finasteride** is actually a correct option for treating hirsutism, as it blocks the conversion of testosterone to dihydrotestosterone (DHT), a potent androgen.

**Clinical Pearl / High-Yield Fact**
A mnemonic to remember the treatment options for hirsutism is "Spi-Fu-Fi" - Spironolactone, Flutamide, and Finasteride are all effective treatments for hirsutism in females.

**Correct Answer:** D.