All of the following inflammatory mediators produce vasoconstriction except
Correct Answer: Bradykinin
Description: Kinins including Bradykinin cause contraction of visceral smooth muscle, but they relax vascular smooth muscle NO, lowering blood pressure. Thromboxane A2 promotes platelet aggregation and vasoconstriction Platelet-activating factor (PAF), a cytokine secreted by neutrophils and monocytes as well as platelets. This compound also has inflammatory activity. It is an ether phospholipid, 1-alkyl-2acetylglyceryl-3-phosphorylcholine, which is produced from membrane lipids. It acts a G protein-coupled receptor to increase the production of arachidonic acid derivatives, including thromboxane A2 which cause vasoconstriction Endothelial cells produce endothelin-1, one of the most potent vasoconstrictor agents yet isolated Ref: Ganong's Review of Medical Physiology Twenty-Third Edition Page No:566
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