All of the following immunohistochemical markers are positive in the neoplastic cells of granulocytic sarcoma, except –
Correct Answer: CD45RO
Description: Granulocytic sarcoma (Chloroma or myeloblastoma)
Granulocytic sarcoma or chloroma is a solid tumor composed of myeloblasts.
A chloroma is an extramedullary manifestation of AML, i.e., it is a solid collection of leukemic cells occurring outside of the bone marrow.
These tumor often have a green tint due to the presence of myeloperoxidase.
Chloromas are more common in monocytic differentiation (M4 & M5 type) AML.
Though chloromas occur most commonly in patients with AML, they may also occur in a patient with : -
Myelodysplastic syndrome
Myeloproliferative syndromes → Myelofibrosis, CML, Polycythemia Vera, Essential thrombocytosis
Without concomitant disease, i.e., Primary chloroma.
Chloromas are positive for : -
CD 68 CD 20 CD 117 Lysozyme
CD 43 CD 34 Myeloperoxidase
Category:
Pathology
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