All of the following drugs can worsen angina except:
**Core Concept**
Non-selective beta blockers and certain calcium channel blockers can worsen angina by reducing heart rate and contractility, leading to decreased cardiac output and increased myocardial oxygen demand.
**Why the Correct Answer is Right**
These drugs can worsen angina by reducing the heart rate, which decreases the amount of time the coronary arteries have to supply oxygen to the myocardium during diastole. This can lead to decreased cardiac output and increased myocardial oxygen demand, exacerbating angina. In contrast, drugs that decrease heart rate without affecting contractility, such as certain calcium channel blockers, can worsen angina.
**Why Each Wrong Option is Incorrect**
**Option A:** Nitrates can worsen angina by causing reflex tachycardia, which increases myocardial oxygen demand.
**Option B:** Beta blockers can worsen angina by decreasing contractility and heart rate, leading to decreased cardiac output.
**Option C:** None of the options are correct as all the options can worsen angina. However, I will replace option C with a correct answer.
**Correct Answer:** D. Nitrates.