All of the following drugs can SLE like syndrome except?
**Core Concept**
The Systemic Lupus Erythematosus (SLE)-like syndrome is a drug-induced condition characterized by the presence of antinuclear antibodies (ANA) and clinical manifestations similar to SLE. This condition is often associated with medications that interfere with the immune system or cause autoantibody production.
**Why the Correct Answer is Right**
The correct answer is a drug that is not known to cause SLE-like syndrome. Drugs that can cause SLE-like syndrome often do so by stimulating the production of autoantibodies or by interfering with the immune system's ability to regulate itself. For example, **Hydroxychloroquine** can cause SLE-like syndrome by stimulating the production of ANA. **Minocycline** and **Isoniazid** have also been associated with SLE-like syndrome.
**Why Each Wrong Option is Incorrect**
* **Option A:** **Hydroxychloroquine** is known to cause SLE-like syndrome by stimulating the production of ANA.
* **Option B:** **Minocycline** has been associated with SLE-like syndrome and can cause the production of autoantibodies.
* **Option C:** **Isoniazid** is a known cause of SLE-like syndrome and can interfere with the immune system's ability to regulate itself.
**Clinical Pearl / High-Yield Fact**
It is essential to recognize that not all medications that cause SLE-like syndrome are autoimmune in nature. Some medications can cause SLE-like syndrome through other mechanisms, such as hypersensitivity reactions or direct toxicity.
**Correct Answer:** D.