All of the following drugs are useful in nephrogenic diabetes insipidus except
Correct Answer: Chlorpropamide
Description: The polyuria and polydipsia of nephrogenic DI are not affected by treatment with standard doses of DDAVP. Treatment with conventional doses of a thiazide diuretic and/or amiloride in conjunction with a low-sodium diet and a prostaglandin synthesis inhibitor (e.g., indomethacin) usually reduces the polyuria and polydipsia by 30-70% and may eliminate them completely in some patients. ref : Harrisons 20th ed 2279.
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