All of the following diuretics inhibit Na+-K+2C1- sympoer, EXCEPT:
Correct Answer: Metolazone
Description: 1 . High efficacy diuretics (Inhibitors of Na-K-2Cl cotranspo) Furosemide, Bumetanide, Torasemide, mersalyl 2.Medium efficacy diuretics {Inhibitors of Na-Cl sympo) (a) Benzothiadiazole (thiazides) Hydrochlorothiazide, Benzthiazide, Hydroflumethiazide, Clopamide (b) Thiazide-like (related heterocyclics) Chlohalidone, Metolazone, Xipamide, Indapamide. 3. Weak or adjunctive diuretics (a) Carbonic anhydrase inhibitors-Acetazolamide (b) Potassium-sparing diuretics (i) Aldosterone antagonist: Spironolactone (ii) Inhibitors of renal epithelial Na+ channel: Triamterene, Amiloride. (c) Osmotic diuretics-Mannitol, Isosorbide, Glycerol (Essentials of medical pharmacology, K.D Tripathi, 6th edition, page 561 )
Category:
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