## Core Concept
The question tests understanding of the cytochrome P450 (CYP) system, specifically the CYP3A subfamily, which is involved in the metabolism of many drugs. CYP3A inhibitors are substances that decrease the activity of the CYP3A enzyme, potentially leading to increased levels of drugs that are normally metabolized by this enzyme.
## Why the Correct Answer is Right
. is known to induce CYP3A, not inhibit it. Inducers increase the expression of the enzyme, leading to faster metabolism of drugs that are substrates for CYP3A.
## Why Each Wrong Option is Incorrect
* **Option A:** is a known inhibitor of CYP3A. It decreases the activity of this enzyme.
* **Option B:** also inhibits CYP3A, affecting drug metabolism.
* **Option D:** is another inhibitor of CYP3A.
## Clinical Pearl / High-Yield Fact
Remembering that rifampicin (a well-known antibiotic) is an inducer of CYP3A, not an inhibitor, is crucial. This is a classic point because it can significantly affect the levels of many drugs when co-administered.
## Correct Answer: .
Free Medical MCQs Β· NEET PG Β· USMLE Β· AIIMS
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