All of the following can cause SLE like syndrome except –
**Core Concept**
SLE (Systemic Lupus Erythematosus) like syndrome is a clinical condition that mimics the manifestations of SLE, but lacks the characteristic autoantibodies and renal involvement. It can be caused by various medications and conditions that trigger an autoimmune response.
**Why the Correct Answer is Right**
The correct answer is a condition that does not typically cause an SLE-like syndrome. SLE-like syndrome can be caused by medications such as:
* Hydralazine, which can trigger the production of anti-histone antibodies.
* Procainamide, which can induce anti-histone antibodies and cause a lupus-like syndrome.
* Infections such as hepatitis B and C, which can trigger an autoimmune response.
* Other conditions such as rheumatoid arthritis and scleroderma, which can also cause an SLE-like syndrome.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because it is a known cause of SLE-like syndrome. For example, hydralazine is a medication that has been associated with the development of anti-histone antibodies and an SLE-like syndrome.
**Option B:** This option is incorrect because it is a condition that can cause an SLE-like syndrome. For example, rheumatoid arthritis is an autoimmune disease that can trigger an SLE-like syndrome.
**Option C:** This option is incorrect because it is a condition that can cause an SLE-like syndrome. For example, hepatitis B and C infections can trigger an autoimmune response and cause an SLE-like syndrome.
**Clinical Pearl / High-Yield Fact**
When considering a patient with an SLE-like syndrome, it is essential to investigate for underlying causes such as medication use, infections, and other autoimmune conditions.
**Correct Answer:** A.