All of the following are true of Eale’s disease except-
**Core Concept**
Eale's disease is a rare, idiopathic, inflammatory disorder affecting the retinal vessels, leading to recurrent episodes of retinal hemorrhages, vitreous hemorrhage, and retinal detachment. It primarily affects young adults and is characterized by its chronic and recurrent nature.
**Why the Correct Answer is Right**
Eale's disease is associated with the presence of retinal neovascularization, which is a hallmark of the disease. This neovascularization leads to the formation of fragile, new blood vessels that are prone to rupture and hemorrhage. The retinal pigment epithelium (RPE) plays a crucial role in the pathogenesis of Eale's disease, as it is involved in the regulation of retinal neovascularization. The exact cause of Eale's disease remains unknown, but it is believed to be related to an autoimmune response or an inflammatory process.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because Eale's disease is indeed associated with retinal neovascularization, which is a key feature of the disease.
**Option B:** This option is incorrect because Eale's disease is not typically associated with diabetes mellitus; it is an idiopathic condition.
**Option C:** This option is incorrect because Eale's disease is not characterized by the presence of retinal tumors or malignancies; it is an inflammatory disorder.
**Clinical Pearl / High-Yield Fact**
Eale's disease is a classic example of a condition that can lead to sudden, severe vision loss due to retinal detachment and vitreous hemorrhage. It is essential for ophthalmologists and primary care physicians to recognize the characteristic symptoms and signs of Eale's disease, such as recurrent retinal hemorrhages and vitreous hemorrhage, to provide timely and effective treatment.
**Correct Answer: B.**