**Core Concept**
Rheumatoid Arthritis (RA) is a chronic autoimmune disorder characterized by inflammation and joint destruction, primarily affecting the small joints of the hands and feet. It is mediated by a complex interplay of immune cells, cytokines, and autoantibodies, particularly rheumatoid factor (RF) and anti-citrullinated protein antibodies (anti-CCP).

**Why the Correct Answer is Right**
Rheumatoid Arthritis is a systemic disease that affects not only the joints but also various other organs and tissues, including the eyes, lungs, heart, and skin. The disease process involves the activation of T-cells and B-cells, leading to the production of pro-inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1β). These cytokines promote inflammation, joint damage, and systemic complications.

**Why Each Wrong Option is Incorrect**
* **Option A:** This option is incorrect because RA is indeed characterized by the presence of rheumatoid factor (RF) and anti-citrullinated protein antibodies (anti-CCP).
* **Option B:** This option is incorrect because RA is a systemic disease that can affect multiple organs and tissues, including the eyes, lungs, heart, and skin.
* **Option C:** This option is incorrect because RA is indeed associated with a higher risk of cardiovascular disease, osteoporosis, and other systemic complications.

**Clinical Pearl / High-Yield Fact**
Early diagnosis and treatment of RA can significantly improve outcomes, including reducing joint damage and preventing systemic complications. The American College of Rheumatology recommends the use of disease-modifying antirheumatic drugs (DMARDs) and biologic agents, such as TNF inhibitors, as first-line therapy for RA.

**Correct Answer: A**