All of the following are true about Kaagener’s syndrome, Except
**Core Concept**
Kartagener's syndrome is a rare genetic disorder characterized by the triad of primary ciliary dyskinesia (PCD), chronic sinusitis, and situs inversus. It is caused by mutations in the DNAI1, DNAH5, or TXNDC3 genes, leading to impaired ciliary function and defective mucociliary clearance.
**Why the Correct Answer is Right**
Kartagener's syndrome is a classic example of a primary ciliary dyskinesia, where the cilia are unable to beat effectively due to defective dynein arms. This results in impaired mucociliary clearance, leading to chronic respiratory tract infections and sinusitis. The situs inversus is thought to be a result of the abnormal embryonic development due to the defective cilia.
**Why Each Wrong Option is Incorrect**
* **Option A:** Kartagener's syndrome is indeed associated with chronic sinusitis and primary ciliary dyskinesia, making this statement true.
* **Option B:** Kartagener's syndrome is indeed characterized by situs inversus, making this statement true.
* **Option C:** Kartagener's syndrome is actually associated with chronic respiratory tract infections and sinusitis, rather than asthma, making this statement false.
**Clinical Pearl / High-Yield Fact**
Kartagener's syndrome is often associated with other conditions such as bronchiectasis, otitis media, and infertility due to immotile sperm. It is essential to diagnose and manage the condition early to prevent long-term complications.
**Correct Answer:** C.