## Core Concept
Darier's disease, also known as keratosis follicularis, is a rare genetic disorder that affects the skin. It is characterized by the abnormal growth of skin cells and is inherited in an autosomal dominant pattern. The condition is caused by mutations in the *ATP2A2* gene, which encodes a protein involved in calcium signaling within cells.

## Why the Correct Answer is Right
The correct answer is related to the characteristics of Darier's disease. The disease presents with skin lesions that are often greasy and wart-like, primarily affecting the face, scalp, ears, and back. Histopathologically, it is marked by suprabasal acantholytic cells and dyskeratotic cells (also known as corps ronds). The condition often worsens with sun exposure, heat, and humidity.

## Why Each Wrong Option is Incorrect
- **Option A:** This option might mention a characteristic feature of Darier's disease, such as greasy wart-like lesions or suprabasal acantholysis, which are indeed true aspects of the condition.
- **Option B:** Similarly, this option could describe another accurate feature, like the autosomal dominant inheritance pattern or the involvement of the *ATP2A2* gene, both of which are correct.
- **Option C:** This could potentially list a common site for the lesions, such as the face or scalp, which aligns with the clinical presentation of Darier's disease.
- **Option D:** This option would represent an incorrect statement about Darier's disease. For example, if it claims that Darier's disease is inherited in an autosomal recessive pattern or that it primarily affects the limbs, it would be incorrect.

## Clinical Pearl / High-Yield Fact
A key point to remember about Darier's disease is its association with *ATP2A2* gene mutations and its characteristic histological features, including corps ronds and suprabasal acantholysis. Clinically, patients often experience exacerbations with heat and sunlight.

## Correct Answer: D.