All of the following are true about 5-flurouracil except

A. It is a purine analogue

B. 5 - flurouracil acts by inhibiting Thymidilate synthase enzyme

C. It can cause hand & foot syndrome

D. It is used along with folinic acid and oxaliplatin for colorectal cancer

Correct Answer: It is a purine analogue

Description: 5-flurouracil is a pyrimidine analogue which is converted to dUMP in the cell and inhibits Thymidilate synthase enzyme. Capecitabine (Prodrug of 5-flurouracil) & 5-flurouracil can cause "Hand & Foot syndrome". FOLFOX regimen (Folinic acid, 5-flurouracil and oxaliplatin) is the DOC for colorectal cancer.

Category: Pharmacology

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