All of the following are symptoms of VlPomas except
**Core Concept**
VlPomas, or Vasoactive Intestinal Polypeptide-secreting tumors, are rare neuroendocrine neoplasms that secrete vasoactive intestinal peptide (VIP). This hormone causes a variety of systemic effects, primarily due to its vasodilatory and secretory properties.
**Why the Correct Answer is Right**
VIPomas lead to a clinical syndrome characterized by excessive secretion of VIP, causing watery diarrhea, hypokalemia, and achlorhydria (WDHA syndrome). The vasodilatory effect of VIP results in hypotension and tachycardia. Additionally, the secretory effect of VIP on the pancreas and gastrointestinal tract leads to hypokalemia, metabolic acidosis, and dehydration.
**Why Each Wrong Option is Incorrect**
**Option A:** While not a primary symptom, abdominal pain can occur in VIPoma patients due to the mass effect of the tumor or secondary to hypokalemia.
**Option B:** Nausea and vomiting are common symptoms of VIPoma patients, often due to the secretory effects of VIP on the gastrointestinal tract.
**Option C:** Weight loss is a common symptom of VIPoma patients, primarily due to the malabsorption of nutrients secondary to the secretory effects of VIP.
**Clinical Pearl / High-Yield Fact**
VIPoma patients often present with a classic triad of symptoms: WDHA syndrome (watery diarrhea, hypokalemia, achlorhydria). This triad is a key diagnostic clue for VIPoma and should prompt further investigation.
**Correct Answer: D.**