All of the following are seen in Goodpasture’s syndrome, except:
**Core Concept**
Goodpasture's syndrome is a rare autoimmune disease characterized by the presence of anti-glomerular basement membrane (anti-GBM) antibodies, leading to pulmonary hemorrhage and rapidly progressive glomerulonephritis. This condition involves the body's immune system attacking the basement membranes of the lungs and kidneys.
**Why the Correct Answer is Right**
The anti-GBM antibodies in Goodpasture's syndrome bind to the alpha-3 chain of type IV collagen in the glomerular basement membrane, causing damage and inflammation. This leads to the characteristic symptoms of pulmonary hemorrhage and rapidly progressive glomerulonephritis. The presence of these antibodies is a key diagnostic feature of Goodpasture's syndrome.
**Why Each Wrong Option is Incorrect**
**Option A:** This is a characteristic feature of Goodpasture's syndrome, as the anti-GBM antibodies cause damage to the glomerular basement membrane, leading to hematuria.
**Option B:** This is also a characteristic feature of Goodpasture's syndrome, as the anti-GBM antibodies cause damage to the alveolar basement membrane, leading to pulmonary hemorrhage.
**Option C:** This is not a characteristic feature of Goodpasture's syndrome, as the condition is not associated with an increased risk of venous thromboembolism.
**Clinical Pearl / High-Yield Fact**
Goodpasture's syndrome is a classic example of an autoimmune disease, where the body's immune system attacks its own tissues, leading to damage and inflammation.
**Correct Answer:** C.