Medical MCQ-All of the following are potentially serious side effects of thioamide group of antithyroid drugs except:

All of the following are potentially serious side effects of thioamide group of antithyroid drugs except:

Hepatic dysfunction

Severe rash

Agranulocytosis

Anaphylaxis

Question Category:

Pharmacology

Correct Answer:

Anaphylaxis

Description:

Ans: D. Anaphylaxis(Ref. Goodman Gilman 12/e p1149; Katzung 13/e p671, 12/e p688)Adverse effects of anti-thyroid drugs:Most serious reaction: AgranulocytosisMC reaction: Mild, purpuric, uicarial papular rash.Less frequent complications: Pain & stiffness in joints, paresthesias, headache, skin pigmentation & loss of hair.ANCAs in -50% of patients receiving propylthiouracil.Cholestatic jaundice - More common with methimazole than propylthiouracil.Propylthiouracil-associated hepatic failure.

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