**Core Concept**
Sarcoidosis is a systemic granulomatous disease characterized by the formation of non-caseating epithelioid cell granulomas in various organs, including the lungs, lymph nodes, skin, and eyes. The pathogenesis of sarcoidosis involves an abnormal immune response, with an imbalance between Th1 and Th2 lymphocytes.

**Why the Correct Answer is Right**
Sarcoidosis is typically a self-limiting disease, and most patients experience spontaneous remission within 2-5 years. The disease can present with a wide range of symptoms, including respiratory symptoms, skin lesions, and eye inflammation. The characteristic non-caseating granulomas are a hallmark of the disease, distinguishing it from other granulomatous conditions like tuberculosis and histoplasmosis.

**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because sarcoidosis can cause hypercalcemia due to increased vitamin D production by activated macrophages within the granulomas.
**Option B:** This option is incorrect because sarcoidosis can cause lymphadenopathy, including enlargement of lymph nodes in the neck, chest, and mediastinum.
**Option C:** This option is incorrect because sarcoidosis can cause uveitis, a form of eye inflammation that can lead to vision loss if left untreated.

**Clinical Pearl / High-Yield Fact**
Sarcoidosis is often associated with an abnormal chest radiograph, with findings such as bilateral hilar lymphadenopathy, pulmonary infiltrates, or Pleural effusion.

**Correct Answer:** D.