ALL of the following are features of acromegaly except-
**Core Concept**
Acromegaly is a hormonal disorder that results from excess growth hormone (GH) production, typically caused by a pituitary adenoma. The excess GH stimulates the production of insulin-like growth factor 1 (IGF-1), leading to various systemic effects on the body.
**Why the Correct Answer is Right**
The features of acromegaly include increased growth of bones, cartilage, and other body tissues, leading to characteristic physical changes such as enlarged hands and feet, prominent facial features, and an increase in height. Other features include joint pain and degeneration, sleep apnea, and an increased risk of developing diabetes mellitus and cardiovascular disease. The excess GH also affects various organs, including the liver, kidneys, and skin, leading to conditions such as hypertension, hypothyroidism, and skin thickening.
**Why Each Wrong Option is Incorrect**
**Option A:** This option is incorrect because acromegaly is characterized by an increase in GH levels, not a decrease. A decrease in GH would lead to growth hormone deficiency.
**Option B:** This option is incorrect because acromegaly is associated with an increase in IGF-1 levels, not a decrease. Elevated IGF-1 levels are a hallmark of acromegaly and are used as a diagnostic marker.
**Option C:** This option is incorrect because acromegaly is associated with an increase in body size, not a decrease. The characteristic physical changes of acromegaly include an increase in height, hand and foot size, and facial features.
**Clinical Pearl / High-Yield Fact**
It's essential to remember that acromegaly can be challenging to diagnose, especially in the early stages, as the symptoms can be nonspecific and similar to those of other conditions. A high index of suspicion and a thorough evaluation of GH and IGF-1 levels are crucial for making an accurate diagnosis.
**Correct Answer: C.**