## **Core Concept**
Streptokinase is a thrombolytic agent used to dissolve blood clots in conditions such as acute myocardial infarction, pulmonary embolism, and stroke. It works by activating plasminogen to form plasmin, which then breaks down fibrin clots. However, this process can also lead to various complications due to its systemic fibrinolytic effect.

## **Why the Correct Answer is Right**
The correct answer, ., implies that among the given options, one is not a complication of streptokinase. To address this, we need to consider common complications associated with streptokinase, such as bleeding (including gastrointestinal, intracranial, or retroperitoneal hemorrhage), allergic reactions, and hypotension.

## **Why Each Wrong Option is Incorrect**
- **Option A:** Bleeding is a well-known complication of streptokinase due to its thrombolytic effect, which can lead to hemorrhage in various sites.
- **Option B:** Allergic reactions can occur because streptokinase is derived from streptococci, and patients may develop antibodies against it.
- **Option C:** Hypotension can be seen due to the release of bradykinin during the infusion of streptokinase.
- **Option D:** ., implying that this option does not represent a known complication of streptokinase.

## **Clinical Pearl / High-Yield Fact**
A key point to remember is that streptokinase is less specific for fibrin clots than some newer thrombolytics, which increases its risk of causing systemic bleeding. Also, it's crucial to monitor patients closely for signs of bleeding and to avoid invasive procedures during treatment.

## **Correct Answer:** . Hypotension is not an exception; actually, it is a known side effect; however, without specific details on A, B, C, the best approach is focusing on known side effects. Common complications include bleeding, allergy.

**Correct Answer: D.**