All of the following are anti-pseudomonal EXCEPT: March 2013
## Core Concept
The question tests knowledge of antibiotics effective against *Pseudomonas aeruginosa*, a type of bacteria that can cause various infections, particularly in immunocompromised individuals. *Pseudomonas* infections are notorious for their resistance to many antibiotics. The correct answer will be an antibiotic that lacks significant activity against *Pseudomonas*.
## Why the Correct Answer is Right
is a first-generation cephalosporin with a narrow spectrum of activity that primarily includes Gram-positive bacteria and some Gram-negative bacteria, but it lacks activity against *Pseudomonas* species. This characteristic makes it stand out from the other options listed, which are known for their anti-pseudomonal properties.
## Why Each Wrong Option is Incorrect
* **Option A:** - This is a -lactam antibiotic with a broad spectrum of activity, including effectiveness against *Pseudomonas* species, making it incorrect as an exception.
* **Option B:** - This is an aminoglycoside antibiotic effective against a wide range of bacteria, including *Pseudomonas*, which is why it's incorrect as an exception.
* **Option D:** - This is a fluoroquinolone antibiotic with broad-spectrum activity, including efficacy against *Pseudomonas*, making it incorrect as an exception.
## Clinical Pearl / High-Yield Fact
A key point to remember is that when treating infections caused by *Pseudomonas aeruginosa*, the choice of antibiotic is critical due to its intrinsic resistance to many antibiotics and its ability to develop resistance rapidly. is not used for *Pseudomonas* infections, whereas the other options can be used.
## Correct Answer: .