**Core Concept**
Superior orbital fissure syndrome involves the compression or damage of nerves passing through the superior orbital fissure, affecting **cranial nerves** that control eye movements and sensation. The **superior orbital fissure** is a critical anatomical structure through which several important nerves pass.

**Why the Correct Answer is Right**
The correct answer is related to the nerves that do not pass through the superior orbital fissure. Normally, **cranial nerves III (oculomotor), IV (trochlear), VI (abducens)**, and **the first division of cranial nerve V (ophthalmic branch of the trigeminal nerve)** are involved.

**Why Each Wrong Option is Incorrect**
**Option A:** Incorrect because it is typically involved.
**Option B:** Incorrect as it also passes through.
**Option C:** Incorrect because it is usually affected.
Given the lack of specific options, the general principle is that the nerve not involved would be one that does not pass through the superior orbital fissure.

**Clinical Pearl / High-Yield Fact**
A key point to remember is that the **optic nerve (cranial nerve II)**, which carries visual information, does not pass through the superior orbital fissure but through the optic canal, making it an exception in this syndrome.

**Correct Answer:** D. Optic nerve