All can be manifestation of polycystic kidney except-
**Core Concept**
Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts filled with fluid in the kidneys, which can lead to kidney enlargement, pain, and eventual kidney failure. The manifestations of PKD can be diverse and may involve various organs and systems.
**Why the Correct Answer is Right**
The manifestations of PKD can include a wide range of symptoms and signs, such as:
* Hematuria (blood in the urine) due to bleeding from cysts or renal papillary necrosis
* Hypertension due to cyst expansion and increased renin production
* Abdominal pain due to cyst rupture or kidney enlargement
* Oligohydramnios or polyhydramnios in pregnancy due to fetal urinary tract obstruction
* Intracranial aneurysms and hemorrhage due to vascular wall fragility
* Liver cysts and cysts in other organs, such as the pancreas and spleen
**Why Each Wrong Option is Incorrect**
**Option A:** This option is not a manifestation of PKD.
**Option B:** This option is not a manifestation of PKD.
**Option C:** This option is not a manifestation of PKD.
**Clinical Pearl / High-Yield Fact**
A key point to remember is that PKD can be associated with other extrarenal manifestations, such as intracranial aneurysms, cardiac valve abnormalities, and skin manifestations like fibromas and angiofibromas.
**Correct Answer:** D.