All are used in management of overdosage of Fibrinolytics except?
Correct Answer: DDAVP
Description: Reversal of Fibrinolytic-Induced Bleeding Minor external bleeding Manual pressure Significant internal bleeding Immediate cessation of fibrinolytic agent, antiplatelet agent, and/or heparin Reversal of heparin with protamine, as discussed earlier Typed and cross-matched blood ordered with verification of activated PTT, CBC, thrombin clotting time, and fibrinogen level Volume replacement with crystalloid and packed red blood cells as needed Major bleeding or hemodynamic compromise All measures listed for significant internal bleeding Fibrinogen concentrate 70 milligrams/kg IV, and recheck fibrinogen level; if fibrinogen level <100 milligrams/dL, repeat fibrinogen concentrate dose. If bleeding persists after fibrinogen concentrate or despite fibrinogen level >100 milligrams/dL, administer FFP 2 units IV. If bleeding continues after FFP, administer an antifibrinolytic such as aminocaproic acid 5 grams IV over 60 min followed by 1 gram/h continuous IV infusion for 8 h or until bleeding stops, or tranexamic acid 10 milligrams/kg IV every 6-8 h. Consider platelet transfusion. Intracranial hemorrhage All measures listed for significant internal and major bleeding with hemodynamic compromise Immediate neurosurgery consultation
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