All are true regarding superantigens except?
Correct Answer: Activate very large numbers of B cells
Description: Superantigens activate very large number of T cells. NON -MHC restricted They are medium sized proteins which Attach to TCR on lateral side on Vb (Variable) domain, outside the antibody binding groove. They cause release of cytokines that induce >20% of T lymphocytes activation resulting in massive proliferation of T lymphocytes. They have high resistance to proteases.
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