Gynaecology & Obstetrics All are true regarding renal changes in normal pregnancy except A Serum creatinine decreases. B GFR and Renal plasma flow increase by 50%. C Increase in serum bicarbonate levels. D Increased placental metabolism of AVP may cause transient diabetes insipidus during pregnancy. 💡 Explanation All are true regarding renal changes in normal pregnancy except ✓ Correct Answer: C. Increase in serum bicarbonate levels.