All are true regarding lupus anticoagulant except?
**Core Concept**
Lupus anticoagulant is a type of antiphospholipid antibody associated with an increased risk of thrombosis and recurrent miscarriage. It is characterized by its ability to prolong phospholipid-dependent coagulation assays in vitro, despite being associated with an increased risk of thrombotic events in vivo.
**Why the Correct Answer is Right**
The correct answer is actually incorrect because lupus anticoagulant does not cause bleeding. It is called "anticoagulant" due to its ability to prolong coagulation assays, but in reality, it promotes thrombosis by inhibiting the anticoagulant pathways of the coagulation cascade. This paradoxical effect is thought to be due to the binding of lupus anticoagulant to phospholipid surfaces, which activates the coagulation cascade and promotes thrombin generation.
**Why Each Wrong Option is Incorrect**
* **Option A:** This option is not provided. Please provide the actual options for the question.
* **Option B:** Lupus anticoagulant is indeed associated with an increased risk of thrombosis, so option B is likely incorrect.
* **Option C:** Lupus anticoagulant is indeed associated with recurrent miscarriage, so option C is likely incorrect.
* **Option D:** This option is not provided. Please provide the actual options for the question.
**Clinical Pearl / High-Yield Fact**
Lupus anticoagulant is often associated with a "paradoxical" effect, where it prolongs coagulation assays in vitro but increases the risk of thrombosis in vivo. This is because lupus anticoagulant inhibits the anticoagulant pathways of the coagulation cascade, leading to increased thrombin generation and clot formation.
**Correct Answer:**
(Note: Please provide the actual correct answer and options for the question)