All are true regarding Lupus anticoagulant, EXCEPT?
Correct Answer: Increased PT
Description: Answer is D or none(Increased PT or none) The Lupus Anticoagulant typically causes an isolated prolongation of APTT. Prothrombin time is usually normal although slight prolongation in PT may also be observed Lupus anticoagulant should be suspected in cases of markedly prolonged PTT without clinical bleeding and normal or slightly elevated PT- CMDT Lupus Anticoagulant Lupus anticoagulant is an `antiphospholipid' seen in about 5 to 10% of cases of SLE The term 'anticoagulant' is a misnomer as LA acts as a procoagulant casuing increased tendency of thrombosis and does not act as an anticoagulant. Lupus anticoagulant is a cause for antiphospholipid syndrome and may present with recurrent thrombosis and pregnancy related morbidity including Recurrent aboions. 'It is mistermed as an 'anticoagulant' because it causes prolongation of PTT in the vitro PTT assay' (This prolongation is produced because lupus anticoagulant being an antiphospholipid binds to the phospholipid used in vitro PTT assays) PT is usually not affected by the lupus anticoagulant.
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